Alain LaederachAssistant Professor
Department of Biology
UNC-Chapel Hill
Research Interests
Computational approaches coupled with high-throughput chemical mapping to understand RNA secondary and tertiary structure and RNA folding. More information on UNC-Chapel Hill page
Selected Publications
High-throughput single-nucleotide structural mapping by capillary automated footprinting analysis (2008) S. Mitra, I. V. Shcherbakova, R. B. Altman, M. Brenowitz, and A. Laederach Nucleic Acids Res. 36, e63 (more ...)
Structural inference of native and partially folded RNA by high-throughput contact mapping (2008) R. Das, M. Kudaravalli, M. Jonikas, A. Laederach, R. Fong, J. P. Schwans, D. Baker, J. A. Piccirilli, R. B. Altman, and D. Herschlag Proc. Natl. Acad. Sci. U S A 105, 4144-4149 (more ...)
Informatics challenges in structured RNA (2007) A. Laederach Brief Bioinform. 8, 294-303 (more ...)
Distinct contribution of electrostatics, initial conformational ensemble, and macromolecular stability in RNA folding. A. Laederach, I. Shcherbakova, M. A. Jonikas, R. B. Altman, M. Brenowitz Proc. Natl. Acad. Sci. U S A 104, 7045-7050. (more ...)
Coplanar and coaxial orientations of RNA bases and helices (2007) A. Laederach, J. M. Chan, A. Schwartzman, E. Willgohs, R. B. Altman RNA 13, 643-650 (more ...)
Lab Members with RNA-related projects
Matt Halvorsen (Graduate Student)
Kate Simmons (Graduate Student)
Lauren Davis (Research Associate)
Abhinab Ray (Graduate Student)
Sam Broadaway (Undergraduate)