Proposals on the structure, maintenance, expression, transfer, stability, and regulation of genetic information with the use of innovative in vivo and/or in vitro approaches are encouraged, as is research at the interfaces of biology, physics, chemistry, mathematics, computer science, and engineering.
Proposals on the structure, function, dynamics, interactions, and interconversions of individual macromolecules through to the large-scale integration of metabolic and energetic processes. Includes development of cutting-edge technologies integrating theoretical, computational, and experimental approaches to the study of biological molecules and their functional complexes; mechanistic studies of the regulation and catalysis of enzymes and RNA, and higher-order characterization of the biochemical processes by which all organisms acquire, transform, and utilize energy from substrates.
Proposals on population variation using empirical and theoretical studies of microevolution, organismal adaptation, geographical differentiation, natural hybridization and speciation, as well as processes that lead to macroevolutionary patterns of trait evolution.
This Funding Opportunity Announcement (FOA) solicits R01 and R03 grant applications for research on non-coding RNAs and other post-transcriptional regulatory mechanisms as they pertain to addictive processes.
This Funding Opportunity Announcement (FOA) solicits R01 and Exploratory/Developmental R21 grant applications for: (1) understanding uptake and processing of RNAi by target tissues, (2) assessing stability, half-life and off-target effects in target tissues, and (3) determining optimal delivery methods for uptake by the target tissues.
This Funding Opportunity Announcement (FOA) solicits R21 grant applications that apply simple genetic interventions (RNA interference or other oligonucleotide-based methods for modifying gene expression) to research projects focused on the prevention and treatment of oral and craniofacial disorders and diseases.